The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins.
Mucin domains are densely O-glycosylated modular protein domains which might be present in all kinds of cell floor and secreted proteins. Mucin-domain glycoproteins are recognized to be key gamers in a number of human ailments, particularly most cancers, whereby mucin expression and glycosylation patterns are altered. Mucin biology has been tough to check on the molecular stage, partially, as a result of …