In Planta Glycan Engineering and Functional Activities of IgE Antibodies.

In Planta Glycan Engineering and Functional Activities of IgE Antibodies.
May 10, 2020 0 Comments

Human immunoglobulin E (IgE) is probably the most extensively glycosylated antibody isotype so glycans hooked up to the seven N–glycosites (NGS) in its Fab and Fc domains could modulate its capabilities. However, focused modification of glycans in multiply glycosylated proteins stays a problem. Here, we utilized an in vivo strategy that permits the manipulation of IgE N-glycans, utilizing a trastuzumab equal IgE …